Faculty Profile

Santanu Bose

Santanu Bose

Professor

santanu.bose@wsu.edu

Office Phone: 509-335-9413
Lab Phone: 509-335-7642

 

Education & Training
BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

Research Interests
Host defense mechanism; antiviral response and inflammation: innate immune antiviral and inflammatory response against respiratory RNA viruses like human respiratory syncytial virus (RSV), and influenza A virus (flu).

Respiratory RNA virus infection and inflammation
Respiratory viruses like RSV, flu cause severe lung disease that manifest as pneumonia and bronchiolitis. These two diseases develop due to massive inflammation in the lung. Therefore, we are investigating the mechanism by which RSV and flu induce inflammation in the lung during infection. Particularly, we are interested in identifying and characterizing cellular factor that regulate inflammation. Our lab is focused on elucidating the mechanism of inflammasome activation by viruses. Inflammasome is an intracellular multi-protein complex involved in initiating inflammation by virtue of controlling production of pro-inflammatory mediators and inducing cell death. Our lab is investigating the biochemical, cellular and molecular mechanism responsible for inflammasome complex formation and activation during infection. Our studies have potential to be developed as therapeutic targets to control inflammation (and associated diseases like pneumonia) during respiratory virus infection.

Innate immune antiviral response against respiratory RNA viruses
We are studying the innate immune response (the first line of defense against pathogens) against RSV and flu. These respiratory viruses are highly pathogenic and cause diseases (pneumonia, bronchiolitis) in children/infants and elderly. We are investigating the mechanism of host derived antiviral immune response to identify novel antiviral molecules/pathways, which could be potentially developed as effective antiviral therapy or used as an immunemodulating adjuvant during vaccination. Our studies on innate immune response constitutes investigation of the role of two signaling pathways, NF-kappa B and interferon-alpa/beta induced JAK/STAT pathways in establishing an antiviral state. The long-term goal of our research is to identify and characterize a) the molecules that play a critical role in activation of these pathways and, b) the antiviral factors that are induced by NF-kappa B and JAK/STAT signaling cascades.

In summary, our laboratory encompasses several aspects of cell and molecular biology/virology with emphasis on 
 a) innate immune antiviral signal transduction pathway, 
 b) cellular/molecular mechanism that triggers inflammation during virus infection, and 
 c) virus-host/cell interaction.

Select Publications:
Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003). Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. 

Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009). Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. 

Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014). DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848.

Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014). ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14.

Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015). Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597.

Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015). Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. 

Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012). Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615.

Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008). Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 

Shil N. K, Pokharel S. M, Banerjee A. K, Hoffman M, Bose S (2018). Inflammasome antagonism by human parainfluenza virus type 3 C protein. J. Virol. 92. pii: e01776-17. 

Thinwa J, Segovia JA, Bose S, Dube PH (2014). Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells. J. Immunol. 193:1373-82. 

Kota S, Echchgadda I, DeLa Cruz I, Sabbah A, Chang T, Harnack R, Mgbemena, Chatterjee B, Bose S (2009). Anti-cancer oncolytic activity of respiratory syncytial virus. Cancer. Gene. Ther. 16: 923-935.

Bose S, Basu M, Banerjee A. K. (2004). Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells. J. Virol. 78: 8146-8158.