Office Phone: 509-335-9413 Lab Phone: 509-335-7642
Education & Training
BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio
Mechanisms regulating inflammation
Chronic and acute inflammation is involved in pathogenesis of various inflammatory diseases like arthritis, cancer, atherosclerosis, septicemia, diabetes. Inflammation is also responsible for causing severe lung diseases like pneumonia and bronchiolitis following infection with respiratory viruses including influenza A virus (flu), human respiratory syncytial virus (RSV) and parainfluenza viruses. In that regard, by utilizing cellular and mice models we are studying the cellular and molecular mechanisms regulating inflammation during flu, RSV and parainfluenza virus infection. Knowledge derived from such studies are important for uncovering the basic mechanisms that regulate inflammatory response during disease states and for development of anti-inflammatory therapeutics to combat inflammatory diseases.
Cellular defense mechanism during virus infection: role of antiviral innate immunity
We are studying the innate immune antiviral response against respiratory viruses including flu, RSV and parainfluenza viruses. Our study focuses on dissecting the host defense mechanism that is involved in launching an innate response constituting of induction of antiviral pathways in the immune cells like macrophages, lung epithelial cells and respiratory tract.
In summary, our laboratory encompasses several aspects of cellular and molecular biology/virology with emphasis on -
a) innate immune antiviral signal transduction pathway,
b) cellular and molecular mechanism that triggers and regulate inflammation, and
c) virus-host/cell interaction.
- Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809
- Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538
- Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357
- Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345
- Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898